3. MYOPATHY

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.

OBJECTIVE In addition to inducing a self-limited myopathy, statin use is associated with an immune-mediated necrotizing myopathy (IMNM), with autoantibodies that recognize ∼200-kd and ∼100-kd autoantigens. The purpose of this study was to identify these molecules to help clarify the disease mechanism and facilitate diagnosis. METHODS The effect of statin treatment on autoantigen expression wa...

Pediatric necrotizing myopathy associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies

OBJECTIVE Antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) have recently been associated with immune-mediated necrotizing myopathy, especially in patients with statin exposure. As the data are very limited concerning phenotypes and treatment in paediatric patients, we aimed to identify the paediatric patients positive for anti-HMGCR antibodies and clarify their feature...

[Thyrotoxic myopathy].

A variety of neuromuscular disorders has been described in adults in association with overactivity of the thyroid (Millikan and Haines, 1953; Ramsay, 1966; Engel, 1972). The most common of these disorders is a chronic myopathy, characterized by muscular atrophy and weakness involving predominantly proximal muscles (Adams and Rosman, 1971). The myopathic symptoms may precede the symptoms of thyr...

Metabolic myopathy.

RECENT years have witnessed a considerably increased interest in disorders of muscle, resulting in large measure from the advent of new investigative techniques. This has led both to the clarification of the nature of known disorders and to the definition of new syndromes. In this review, a brief survey is given of current knowledge concerning myopathic disorders arising from metabolic disturba...

Chloroquine myopathy.